USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P49454

USC-OGP 2-DE database:  P49454


General information about the entry
View entry in simple text format
Primary accession numberP49454
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Centromere protein F; Short=CENP-F; AltName: Full=AH antigen; AltName: Full=Kinetochore protein CENPF; AltName: Full=Mitosin; Flags: Precursor;.
Gene nameName=CENPF
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
  map experimental info

pI=5.77; Mw=83686

UniProtKB/Swiss-ProtP49454; CENPF_HUMAN.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Primary accession numberP49454
Secondary accession number(s) Q13171 Q13246 Q5VVM7
Sequence was last modified on August 21, 2007 (version 2)
Annotations were last modified on March 15, 2017 (version 172)
Name and origin of the protein
DescriptionRecName: Full=Centromere protein F; Short=CENP-F; AltName: Full=AH antigen; AltName: Full=Kinetochore protein CENPF; AltName: Full=Mitosin; Flags: Precursor;
Gene nameName=CENPF
Encoded onName=CENPF
KeywordsAcetylation; Cell cycle; Cell division; Centromere; Chromosome; Ciliopathy; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; DNA synthesis; Kinetochore; Lipoprotein; Methylation; Mitosis; Myogenesis; Nucleus; Phosphoprotein; Polymorphism; Prenylation; Primary ciliary dyskinesia; Reference proteome; Repeat.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU19769; AAA82889.1; -; mRNA
EMBLU30872; AAA82935.1; -; mRNA
EMBLAL445666; CAH71810.1; -; Genomic_DNA
EMBLAL445305; CAH71810.1; JOINED; Genomic_DNA
EMBLAL445305; CAH73032.1; -; Genomic_DNA
EMBLAL445666; CAH73032.1; JOINED; Genomic_DNA
EMBLBC172232; AAI72232.1; -; mRNA
EMBLU25725; AAA86889.1; -; mRNA
PIRPC4035; PC4035; .
RefSeqNP_057427.3; NM_016343.3; .
UniGeneHs.497741; -; .
ProteinModelPortalP49454; -; .
SMRP49454; -; .
BioGrid107492; 47; .
IntActP49454; 27; .
MINTMINT-2803614; -; .
STRING9606.ENSP00000355922; -; .
iPTMnetP49454; -; .
PhosphoSitePlusP49454; -; .
BioMutaCENPF; -; .
DMDM156630875; -; .
EPDP49454; -; .
MaxQBP49454; -; .
PaxDbP49454; -; .
PeptideAtlasP49454; -; .
PRIDEP49454; -; .
EnsemblENST00000366955; ENSP00000355922; ENSG00000117724; .
GeneID1063; -; .
KEGGhsa:1063; -; .
UCSCuc001hkm.4; human; .
CTD1063; -; .
DisGeNET1063; -; .
GeneCardsCENPF; -; .
H-InvDBHIX0028827; -; .
HPACAB009581; -; .
HPAHPA052382; -; .
MalaCardsCENPF; -; .
MIM243605; phenotype; .
MIM600236; gene; .
neXtProtNX_P49454; -; .
PharmGKBPA26401; -; .
eggNOGENOG410IGJF; Eukaryota; .
HOVERGENHBG050893; -; .
InParanoidP49454; -; .
KOK11499; -; .
OrthoDBEOG091G01XR; -; .
PhylomeDBP49454; -; .
TreeFamTF101133; -; .
ReactomeR-HSA-156711; Polo-like kinase mediated events; .
ReactomeR-HSA-2467813; Separation of Sister Chromatids; .
ReactomeR-HSA-2500257; Resolution of Sister Chromatid Cohesion; .
ReactomeR-HSA-5663220; RHO GTPases Activate Formins; .
ReactomeR-HSA-68877; Mitotic Prometaphase; .
ChiTaRSCENPF; human; .
GeneWikiCENPF; -; .
GenomeRNAi1063; -; .
PROPR:P49454; -; .
ProteomesUP000005640; Chromosome 1; .
BgeeENSG00000117724; -; .
CleanExHS_CENPF; -; .
ExpressionAtlasP49454; baseline and differential; .
GenevisibleP49454; HS; .
GOGO:0005930; C:axoneme; IEA:Ensembl; .
GOGO:0005813; C:centrosome; IEA:Ensembl; .
GOGO:0000775; C:chromosome; centromeric region; IDA:UniProtKB
GOGO:0036064; C:ciliary basal body; IEA:Ensembl; .
GOGO:0097539; C:ciliary transition fiber; IMP:GO_Central; .
GOGO:0000940; C:condensed chromosome outer kinetochore; IDA:UniProtKB; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0000776; C:kinetochore; IDA:UniProtKB; .
GOGO:0030496; C:midbody; IDA:UniProtKB; .
GOGO:0005635; C:nuclear envelope; IDA:UniProtKB; .
GOGO:0016363; C:nuclear matrix; IDA:UniProtKB; .
GOGO:0005654; C:nucleoplasm; IDA:HPA; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell; .
GOGO:0045120; C:pronucleus; IEA:Ensembl; .
GOGO:0005819; C:spindle; IDA:UniProtKB; .
GOGO:0000922; C:spindle pole; IDA:UniProtKB; .
GOGO:0003682; F:chromatin binding; NAS:UniProtKB; .
GOGO:0070840; F:dynein complex binding; IDA:UniProtKB; .
GOGO:0008022; F:protein C-terminus binding; IPI:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; IPI:UniProtKB; .
GOGO:0008134; F:transcription factor binding; IPI:UniProtKB; .
GOGO:0030154; P:cell differentiation; IEA:UniProtKB-KW; .
GOGO:0051301; P:cell division; IEA:UniProtKB-KW; .
GOGO:0008283; P:cell proliferation; NAS:UniProtKB; .
GOGO:0007059; P:chromosome segregation; IMP:UniProtKB; .
GOGO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW; .
GOGO:0001822; P:kidney development; IMP:GO_Central; .
GOGO:0051382; P:kinetochore assembly; NAS:UniProtKB; .
GOGO:0051310; P:metaphase plate congression; IDA:UniProtKB; .
GOGO:0000278; P:mitotic cell cycle; IMP:UniProtKB; .
GOGO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW; .
GOGO:0007094; P:mitotic spindle assembly checkpoint; NAS:UniProtKB; .
GOGO:0007517; P:muscle organ development; IEA:UniProtKB-KW; .
GOGO:0045892; P:negative regulation of transcription; DNA-templated; IDA:UniProtKB
GOGO:0015031; P:protein transport; IDA:UniProtKB; .
GOGO:0051726; P:regulation of cell cycle; TAS:Reactome; .
GOGO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IMP:UniProtKB; .
GOGO:0016202; P:regulation of striated muscle tissue development; ISS:UniProtKB; .
GOGO:0042493; P:response to drug; NAS:UniProtKB; .
GOGO:0007062; P:sister chromatid cohesion; TAS:Reactome; .
GOGO:0021591; P:ventricular system development; IMP:GO_Central; .
InterProIPR018302; CenpF/LEK1_Rb-prot-bd; .
InterProIPR019513; Centromere_CenpF_leu-rich_rpt; .
InterProIPR018463; Centromere_CenpF_N; .
PfamPF10490; CENP-F_C_Rb_bdg; 1; .
PfamPF10473; CENP-F_leu_zip; 3; .
PfamPF10481; CENP-F_N; 1; .

USC-OGP 2-DE database image

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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server